Inhibition of Caspase 3 Abrogates Lipopolysaccharide-Induced Nitric Oxide Production by Preventing Activation of NF-κB and c-Jun NH(2)-Terminal Kinase/Stress-Activated Protein Kinase in RAW 264.7 Murine Macrophage Cells

The effect of caspase inhibitors on lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW 267.4 murine macrophage cells was investigated. Pretreatment of RAW cells with a broad caspase inhibitor, benzyloxycarbonyl-Val-Ala-Asp-fluoromethylketone (Z-VAD-FMK), resulted in a striking redu...

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Bibliographic Details
Main Authors: Chakravortty, Dipshikha, Kato, Yutaka, Sugiyama, Tsuyoshi, Koide, Naoki, Mu, Mya Mya, Yoshida, Tomoaki, Yokochi, Takashi
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Host Response and Inflammation
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC98022/
https://ncbi.nlm.nih.gov/pubmed/11179293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.3.1315-1321.2001
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