Expression, Extracellular Secretion, and Immunogenicity of the Plasmodium falciparum Sporozoite Surface Protein 2 in Salmonella Vaccine Strains

Deleting transmembrane α-helix motifs from Plasmodium falciparum sporozoite surface protein (SSP-2) allowed its secretion from Salmonella enterica serovar Typhimurium SL3261 and S. enterica serovar Typhi CVD 908-htrA by the Hly type I secretion system. In mice immunized intranasally, serovar Typhimu...

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Autores principales: Gómez-Duarte, Oscar G., Pasetti, Marcela F., Santiago, Araceli, Sztein, Marcelo B., Hoffman, Stephen L., Levine, Myron M.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2001
Materias:
Fungal and Parasitic Infections
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC98005/
https://ncbi.nlm.nih.gov/pubmed/11160021
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.2.1192-1198.2001
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