Staphylococcus aureus Cap5O Has UDP-ManNAc Dehydrogenase Activity and Is Essential for Capsule Expression

The Staphylococcus aureus serotype 5 capsular polysaccharide (CP5) has a repeating unit composed of (→4)-3-O-acetyl-β-d-ManNAcA-(1→4)-α-l-FucNAc (1→3)-β-d-FucNAc-(1→)(n). Sixteen chromosomal genes (cap5A through cap5P) are involved in the synthesis of CP5. We recently demonstrated that Cap5P, a 2-ep...

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Bibliographische Detailangaben
Hauptverfasser: Portolés, Marta, Kiser, Kevin B., Bhasin, Navneet, Chan, Kenneth H. N., Lee, Jean C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Molecular Pathogenesis
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC97970/
https://ncbi.nlm.nih.gov/pubmed/11159986
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.2.917-923.2001
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