Synthetic 6B Di-, Tri-, and Tetrasaccharide-Protein Conjugates Contain Pneumococcal Type 6A and 6B Common and 6B- Specific Epitopes That Elicit Protective Antibodies in Mice

The immunogenicity and protective capacity of Streptococcus pneumoniae 6B capsular polysaccharide (PS)-derived synthetic phosphate-containing disaccharide (Rha-ribitol-P-), trisaccharide (ribitol-P-Gal-Glc-), and tetrasaccharide (Rha-ribitol-P-Gal-Glc-)-protein conjugates in rabbits and mice were st...

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Main Authors: Jansen, Wouter T. M., Hogenboom, Sietske, Thijssen, Mark J. L., Kamerling, Johannis P., Vliegenthart, Johannes F. G., Verhoef, Jan, Snippe, Harm, Verheul, André F. M.
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2001
Teme:
Microbial Immunity and Vaccines
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC97953/
https://ncbi.nlm.nih.gov/pubmed/11159969
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.69.2.787-793.2001
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