Lack of Protection in Mice and Necrotizing Bronchointerstitial Pneumonia with Bronchiolitis in Guinea Pigs Immunized with Vaccines Directed against the hsp60 Molecule of Mycobacterium tuberculosis

In this study, the hsp60 and hsp70 heat shock protein antigens of Mycobacterium tuberculosis were tested as potential vaccine candidates, using purified recombinant protein antigens or antigens encoded in the form of a DNA plasmid vaccine. Guinea pigs vaccinated with a mixture of the two proteins sh...

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Main Authors: Turner, Oliver C., Roberts, Alan D., Frank, Anthony A., Phalen, Susan W., McMurray, David M., Content, Jean, Denis, Olivier, D'Souza, Sushila, Tanghe, Audrey, Huygen, Kris, Orme, Ian M.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
Fag:
Microbial Immunity and Vaccines
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC97658/
https://ncbi.nlm.nih.gov/pubmed/10816527
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