RNase H mediated cleavage of RNA by cyclohexene nucleic acid (CeNA)

Cyclohexene nucleic acid (CeNA) forms a duplex with RNA that is more stable than a DNA–RNA duplex (ΔT(m) per modification: +2°C). A cyclohexenyl A nucleotide adopts a 3′-endo conformation when introduced in dsDNA. The neighbouring deoxynucleotide adopts an O4′-endo conformation. The CeNA:RNA duplex...

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Pubblicato in:	Nucleic Acids Res
Autori principali:	Verbeure, Birgit, Lescrinier, Eveline, Wang, Jing, Herdewijn, Piet
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Oxford University Press 2001
Soggetti:	Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97599/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11812823/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.24.4941
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