RNase H mediated cleavage of RNA by cyclohexene nucleic acid (CeNA)
Cyclohexene nucleic acid (CeNA) forms a duplex with RNA that is more stable than a DNA–RNA duplex (ΔT(m) per modification: +2°C). A cyclohexenyl A nucleotide adopts a 3′-endo conformation when introduced in dsDNA. The neighbouring deoxynucleotide adopts an O4′-endo conformation. The CeNA:RNA duplex...
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| Veröffentlicht in: | Nucleic Acids Res |
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| Hauptverfasser: | , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Oxford University Press
2001
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| Schlagworte: | |
| Online-Zugang: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97599/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11812823/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.24.4941 |
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