A mutation in the primer grip region of HIV-1 reverse transcriptase that confers reduced fidelity of DNA synthesis
A compensatory mutation (M230I) in the primer grip of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) restores the replication capacity of virus having a Y115W mutation in their RT coding region. The Y115W substitution impairs DNA polymerase activity and produces an enzyme wit...
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| Publicado en: | Nucleic Acids Res |
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| Autores principales: | , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
Oxford University Press
2001
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97574/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11812826/ https://ncbi.nlm.nih.govhttps://doi.org/10.1093/nar/29.24.4963 |
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