Synthetic Peptide Immunogens Elicit Polyclonal and Monoclonal Antibodies Specific for Linear Epitopes in the D Motifs of Staphylococcus aureus Fibronectin-Binding Protein, Which Are Composed of Amino Acids That Are Essential for Fibronectin Binding

A fibronectin (Fn)-binding adhesin of Staphylococcus aureus contains three tandem 37- or 38-amino-acid motifs (D1, D2, and D3), which function to bind Fn. Plasma from patients with S. aureus infections contain antibodies that preferentially recognize ligand induced binding sites in the D motifs and...

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Bibliografiske detaljer

Udgivet i:	Infect Immun
Principais autores:	Huesca, Mario, Sun, Qing, Peralta, Robert, Shivji, Gulnar M., Sauder, Daniel N., McGavin, Martin J.
Format:	Artigo
Sprog:	Inglês
Udgivet:	American Society for Microbiology (ASM) 2000
Fag:	Molecular and Cellular Pathogenesis
Online adgang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97261/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10678920/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.3.1156-1163.2000
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