Evaluation of the Virulence of a Streptococcus pneumoniae Neuraminidase-Deficient Mutant in Nasopharyngeal Colonization and Development of Otitis Media in the Chinchilla Model

Considerable evidence has implicated Streptococcus pneumoniae neuraminidase in the pathogenesis of otitis media (OM); however, its exact role has not been conclusively established. Recently, an S. pneumoniae neuraminidase-deficient mutant, ΔNA1, has been constructed by insertion-duplication mutagene...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Tong, H. H., Blue, L. E., James, M. A., DeMaria, T. F.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Bacterial Infections
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97223/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10639464/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.2.921-924.2000
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