Intranasal Immunization of Mice with a Mixture of the Pneumococcal Proteins PsaA and PspA Is Highly Protective against Nasopharyngeal Carriage of Streptococcus pneumoniae

Acquisition of pneumococci is generally from carriers rather than from infected individuals. Therefore, to induce herd immunity against Streptococcus pneumoniae it will be necessary to elicit protection against carriage. Capsular polysaccharide-protein conjugates, PspA, and PsaA are known to elicit...

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Detalhes bibliográficos
Main Authors: Briles, David E., Ades, Eddie, Paton, James C., Sampson, Jacquelyn S., Carlone, George M., Huebner, Robert C., Virolainen, Anni, Swiatlo, Edwin, Hollingshead, Susan K.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2000
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC97207/
https://ncbi.nlm.nih.gov/pubmed/10639448
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