Enhanced Production of Recombinant Mycobacterium tuberculosis Antigens in Escherichia coli by Replacement of Low-Usage Codons

A major obstacle to development of subunit vaccines and diagnostic reagents for tuberculosis is the inability to produce large quantities of these proteins. To test the hypothesis that poor expression of some mycobacterial genes in Escherichia coli is due, in part, to the presence of low-usage E. co...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Lakey, David L., Voladri, Rama K. R., Edwards, Kathryn M., Hager, Cynthia, Samten, Buka, Wallis, Robert S., Barnes, Peter F., Kernodle, Douglas S.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Bacterial Infections
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97126/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10603393/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.1.233-238.2000
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