Development of a ΔglnA Balanced Lethal Plasmid System for Expression of Heterologous Antigens by Attenuated Vaccine Vector Strains of Vibrio cholerae

We have previously shown that more prominent immune responses are induced to antigens expressed from multicopy plasmids in live attenuated vaccine vector strains of Vibrio cholerae than to antigens expressed from single-copy genes on the V. cholerae chromosome. Here, we report the construction of a...

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Veröffentlicht in:	Infect Immun
Hauptverfasser:	Ryan, Edward T., Crean, Thomas I., Kochi, Sims K., John, Manohar, Luciano, Angel A., Killeen, Kevin P., Klose, Karl E., Calderwood, Stephen B.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Microbial Immunity and Vaccines
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97124/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10603391/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.68.1.221-226.2000
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