Cytotoxic Necrotizing Factor Type 2 Produced by Pathogenic Escherichia coli Deamidates a Gln Residue in the Conserved G-3 Domain of the Rho Family and Preferentially Inhibits the GTPase Activity of RhoA and Rac1

Cytotoxic necrotizing factor types 1 and 2 (CNF1 and -2) produced by pathogenic Escherichia coli strains have 90% conserved residues over 1,014-amino-acid sequences. Both CNFs are able to provoke a remarkable increase in F-actin structures in cultured cells and covalently modify the RhoA small GTPas...

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Publicado en:	Infect Immun
Autores principales:	Sugai, Motoyuki, Hatazaki, Kiyotaka, Mogami, Akira, Ohta, Hiroyuki, Pérès, Sylvie Y., Hérault, Fredéric, Horiguchi, Yasuhiko, Masuda, Minako, Ueno, Yoko, Komatsuzawa, Hitoshi, Suginaka, Hidekazu, Oswald, Eric
Formato:	Artigo
Lenguaje:	Inglês
Publicado:	American Society for Microbiology (ASM) 1999
Materias:	Molecular and Cellular Pathogenesis
Acceso en línea:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97066/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10569774/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.12.6550-6557.1999
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