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Randomized, Double-Blind, Placebo-Controlled, Multicentered Trial of the Efficacy of a Single Dose of Live Oral Cholera Vaccine CVD 103-HgR in Preventing Cholera following Challenge with Vibrio cholerae O1 El Tor Inaba Three Months after Vaccination

CVD 103-HgR is a live oral cholera vaccine strain constructed by deleting 94% of the gene for the enzymatically active A subunit of cholera toxin from classical Inaba Vibrio cholerae O1 569B; the strain also contains a mercury resistance gene as an identifying marker. This vaccine was well tolerated...

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Sparad:
I publikationen:Infect Immun
Huvudupphov: Tacket, Carol O., Cohen, Mitchell B., Wasserman, Steven S., Losonsky, Genevieve, Livio, Sofie, Kotloff, Karen, Edelman, Robert, Kaper, James B., Cryz, Stanley J., Giannella, Ralph A., Schiff, Gilbert, Levine, Myron M.
Materialtyp: Artigo
Språk:Inglês
Utgiven: American Society for Microbiology (ASM) 1999
Ämnen:
Microbial Immunity and Vaccines
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC97039/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10569747/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.12.6341-6345.1999
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