Intranasal Immunization with Pneumococcal Polysaccharide Conjugate Vaccines with Nontoxic Mutants of Escherichia coli Heat-Labile Enterotoxins as Adjuvants Protects Mice against Invasive Pneumococcal Infections

Host defenses against Streptococcus pneumoniae depend largely on phagocytosis following opsonization by polysaccharide-specific immunoglobulin G (IgG) antibodies and complement. Since colonization of the respiratory mucosa is the first step in pneumococcal pathogenesis, mucosal immune responses may...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Jakobsen, Håvard, Schulz, Dominique, Pizza, Mariagrazia, Rappuoli, Rino, Jónsdóttir, Ingileif
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Microbial Immunity and Vaccines
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96971/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10531245/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.11.5892-5897.1999
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