Identification of a Clostridium perfringens Enterotoxin Region Required for Large Complex Formation and Cytotoxicity by Random Mutagenesis

Clostridium perfringens enterotoxin (CPE), a single polypeptide of 319 amino acids, has a unique multistep mechanism of action. In the first step, CPE binds to claudin proteins and/or a 50-kDa eukaryotic membrane protein receptor, forming a small (∼90-kDa) complex. This small complex apparently then...

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Detalhes bibliográficos

Publicado no:	Infect Immun
Principais autores:	Kokai-Kun, John F., Benton, Kimberly, Wieckowski, Eva U., McClane, Bruce A.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Molecular and Cellular Pathogenesis
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96936/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10531210/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.11.5634-5641.1999
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