Polarization of the Immune Response to the Single Immunodominant Epitope of p38, a Major Schistosoma mansoni Egg Antigen, Generates Th1- or Th2-Type Cytokines and Granulomas
In schistosomiasis mansoni, helminth eggs secrete soluble egg antigens (SEA) that induce T-cell-mediated granulomatous tissue responses. The cloned 38-kDa peptide (p38) of SEA was shown to induce and elicit Th1-type responsiveness in H-2(k) mice. Subsequently, the immunodominant T-cell epitope (P4)...
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| Publié dans: | Infect Immun |
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| Auteurs principaux: | , |
| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology (ASM)
1999
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC96780/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10456902/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/iai.67.9.4570-4577.1999 |
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