Resistance to Both Complement Activation and Phagocytosis in Type 3 Pneumococci Is Mediated by the Binding of Complement Regulatory Protein Factor H

To study the role of surface-associated proteins in the virulence of Streptococcus pneumoniae, we used two serotype 3 strains, ATCC 6303 and WU2, and two PspA-negative mutants of WU2, an encapsulated one, JY1123 (Caps(+)/PspA(−)), and an unencapsulated one, DW3.8 (Caps(−)/PspA(−)). ATCC 6303 and WU2...

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Detalhes bibliográficos
Main Authors: Neeleman, Chris, Geelen, Sibyl P. M., Aerts, Piet C., Daha, Mohammed R., Mollnes, Tom E., Roord, John J., Posthuma, George, van Dijk, Hans, Fleer, André
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 1999
Assuntos:
Molecular and Cellular Pathogenesis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC96772/
https://ncbi.nlm.nih.gov/pubmed/10456894
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