Intracellular Tryptophan Pool Sizes May Account for Differences in Gamma Interferon-Mediated Inhibition and Persistence of Chlamydial Growth in Polarized and Nonpolarized Cells

Gamma interferon (IFN-γ) is an important factor in the modulating inhibition of intracellular chlamydial growth and persistence. In human epithelial cells and macrophages, this inhibition is the result of depletion of the essential amino acid tryptophan via the IFN-γ-induced enzyme indoleamine 2,3-d...

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Autors principals: Kane, Colleen D., Vena, Renee M., Ouellette, Scot P., Byrne, Gerald I.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 1999
Matèries:
Molecular and Cellular Pathogenesis
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC96511/
https://ncbi.nlm.nih.gov/pubmed/10085001
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