Gamma Interferon Augments Macrophage Activation by Lipopolysaccharide by Two Distinct Mechanisms, at the Signal Transduction Level and via an Autocrine Mechanism Involving Tumor Necrosis Factor Alpha and Interleukin-1

When given in the presence of gamma interferon (IFN-γ), otherwise nontoxic doses of lipopolysaccharide (LPS or endotoxin) become highly lethal for mice. The mechanisms of this synergistic toxicity are not known. We considered the possibility that an interaction between the LPS-induced NF-κB and IFN-...

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Hlavní autoři: Held, Thomas K., Weihua, Xiao, Yuan, Liang, Kalvakolanu, Dhananjaya V., Cross, Alan S.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 1999
Témata:
Host Response and Inflammation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC96298/
https://ncbi.nlm.nih.gov/pubmed/9864217
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