A Point Mutation in a Domain of Gamma Interferon Receptor 1 Provokes Severe Immunodeficiency

Gamma interferon (IFN-γ) and the cellular responses induced by it are essential for controlling mycobacterial infections. Most patients bearing an IFN-γ receptor ligand-binding chain (IFN-γR1) deficiency present gross mutations that truncate the protein and prevent its expression, giving rise to sev...

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Main Authors: Allende, Luis M., López-Goyanes, Alberto, Paz-Artal, Estela, Corell, Alfredo, García-Pérez, M. Angel, Varela, Pilar, Scarpellini, Atilio, Negreira, Sagrario, Palenque, Elia, Arnaiz-Villena, Antonio
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2001
Assuntos:
Immune-Mediated Responses and Disorders
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC96022/
https://ncbi.nlm.nih.gov/pubmed/11139207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CDLI.8.1.133-137.2001
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