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Transcription of the Gene Mediating Methicillin Resistance in Staphylococcus aureus (mecA) Is Corepressed but Not Coinduced by Cognate mecA and β-Lactamase Regulators

Resistance to β-lactam antibiotics in staphylococci is mediated by mecA and blaZ, genes encoding a penicillin-binding protein (PBP2a) with low β-lactam affinity and β-lactamase, respectively. The mec and bla regulators, mecR1-mecI and blaR1-blaI, respectively, encode inducer-repressors with sufficie...

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Udgivet i:J Bacteriol
Principais autores: McKinney, Tanya K., Sharma, Vijay K., Craig, William A., Archer, Gordon L.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Genetics and Molecular Biology
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC95527/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11698375/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.183.23.6862-6868.2001
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