Functional Complementation of Pyran Ring Formation in Actinorhodin Biosynthesis in Streptomyces coelicolor A3(2) by Ketoreductase Genes for Granaticin Biosynthesis

A mutation in actVI-ORF1, which controls C-3 reduction in actinorhodin biosynthesis by Streptomyces coelicolor, was complemented by gra-ORF5 and -ORF6 from the granaticin biosynthetic gene cluster of Streptomyces violaceoruber Tü22. It is hypothesized that, while gra-ORF5 alone is a ketoreductase fo...

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Pubblicato in:	J Bacteriol
Autori principali:	Ichinose, Koji, Taguchi, Takaaki, Bedford, David J., Ebizuka, Yutaka, Hopwood, David A.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Physiology and Metabolism
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC95226/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11325954/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.183.10.3247-3250.2001
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