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Twelve-Transmembrane-Segment (TMS) Version (ΔTMS VII-VIII) of the 14-TMS Tet(L) Antibiotic Resistance Protein Retains Monovalent Cation Transport Modes but Lacks Tetracycline Efflux Capacity
A “Tet(L)-12” version of Tet(L), a tetracycline efflux protein with 14 transmembrane segments (TMS), was constructed by deletion of two central TMS. Tet(L)-12 catalyzed Na(+)/H(+) antiport and antiport with K(+) as a coupling ion as well as or better than wild-type Tet(L) but exhibited no tetracycli...
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| Autors principals: | , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
American Society for Microbiology
2001
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC95185/ https://ncbi.nlm.nih.gov/pubmed/11274128 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.183.8.2667-2671.2001 |
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