A Mutation in the 5′ Untranslated Region Increases Stability of norA mRNA, Encoding a Multidrug Resistance Transporter of Staphylococcus aureus

NorA, a multidrug efflux pump in Staphylococcus aureus, protects the cell from multiple drugs, including quinolones. The flqB mutation (T→G) in the 5′ untranslated region upstream of norA causes norA overexpression of 4.9-fold in cis, as measured in norA::blaZ fusions. The transcriptional initiation...

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Detalhes bibliográficos
Main Authors: Fournier, Bénédicte, Truong-Bolduc, Que Chi, Zhang, Xiamei, Hooper, David C.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2001
Assuntos:
Genetics and Molecular Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC95146/
https://ncbi.nlm.nih.gov/pubmed/11244079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.183.7.2367-2371.2001
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