MeaA, a Putative Coenzyme B(12)-Dependent Mutase, Provides Methylmalonyl Coenzyme A for Monensin Biosynthesis in Streptomyces cinnamonensis

The ratio of the major monensin analogs produced by Streptomyces cinnamonensis is dependent upon the relative levels of the biosynthetic precursors methylmalonyl-coenzyme A (CoA) (monensin A and monensin B) and ethylmalonyl-CoA (monensin A). The meaA gene of this organism was cloned and sequenced an...

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Bibliographic Details
Main Authors: Zhang, Weiwen, Reynolds, Kevin A.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Physiology and Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC95104/
https://ncbi.nlm.nih.gov/pubmed/11222607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JB.183.6.2071-2080.2001
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