Targeted Inactivation of the mecB Gene, Encoding Cystathionine-γ-Lyase, Shows that the Reverse Transsulfuration Pathway Is Required for High-Level Cephalosporin Biosynthesis in Acremonium chrysogenum C10 but Not for Methionine Induction of the Cephalosporin Genes

Targeted gene disruption efficiency in Acremonium chrysogenum was increased 10-fold by applying the double-marker enrichment technique to this filamentous fungus. Disruption of the mecB gene by the double-marker technique was achieved in 5% of the transformants screened. Mutants T6 and T24, obtained...

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Pubblicato in:	J Bacteriol
Autori principali:	Liu, Gang, Casqueiro, Javier, Bañuelos, Oscar, Cardoza, Rosa E., Gutiérrez, Santiago, Martín, Juan F.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Physiology and Metabolism
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC95063/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11160109/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/JB.183.5.1765-1772.2001
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