Characterization of a Thermostable DNA Glycosylase Specific for U/G and T/G Mismatches from the Hyperthermophilic Archaeon Pyrobaculum aerophilum

U/G and T/G mismatches commonly occur due to spontaneous deamination of cytosine and 5-methylcytosine in double-stranded DNA. This mutagenic effect is particularly strong for extreme thermophiles, since the spontaneous deamination reaction is much enhanced at high temperature. Previously, a U/G and...

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Veröffentlicht in:	J Bacteriol
Hauptverfasser:	Yang, Hanjing, Fitz-Gibbon, Sorel, Marcotte, Edward M., Tai, Jennifer H., Hyman, Elizabeth C., Miller, Jeffrey H.
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	American Society for Microbiology (ASM) 2000
Schlagworte:	Enzymes and Proteins
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC94412/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10671447/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.182.5.1272-1279.2000
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