Insertional Inactivation of Methylmalonyl Coenzyme A (CoA) Mutase and Isobutyryl-CoA Mutase Genes in Streptomyces cinnamonensis: Influence on Polyketide Antibiotic Biosynthesis

The coenzyme B(12)-dependent isobutyryl coenzyme A (CoA) mutase (ICM) and methylmalonyl-CoA mutase (MCM) catalyze the isomerization of n-butyryl-CoA to isobutyryl-CoA and of methylmalonyl-CoA to succinyl-CoA, respectively. The influence that both mutases have on the conversion of n- and isobutyryl-C...

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Detalles Bibliográficos

Publicado en:	J Bacteriol
Principais autores:	Vrijbloed, Jan W., Zerbe-Burkhardt, Katja, Ratnatilleke, Ananda, Grubelnik-Leiser, Andreas, Robinson, John A.
Formato:	Artigo
Idioma:	Inglês
Publicado:	American Society for Microbiology (ASM) 1999
Assuntos:	Genetics and Molecular Biology
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC94078/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10482499/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.181.18.5600-5605.1999
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