Metal-Catalyzed Oxidation of Phenylalanine-Sensitive 3-Deoxy-d-arabino-Heptulosonate-7-Phosphate Synthase from Escherichia coli: Inactivation and Destabilization by Oxidation of Active-Site Cysteines

The in vitro instability of the phenylalanine-sensitive 3-deoxy-d-arabino-heptulosonate-7-phosphate synthase [DAHPS(Phe)] from Escherichia coli has been found to be due to a metal-catalyzed oxidation mechanism. DAHPS(Phe) is one of three differentially feedback-regulated isoforms of the enzyme which...

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Detalhes bibliográficos

Publicado no:	J Bacteriol
Principais autores:	Park, Ohkmae K., Bauerle, Ronald
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 1999
Assuntos:	Enzymes and Proteins
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC93556/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10049398/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/jb.181.5.1636-1642.1999
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