Applications of Gene Replacement Technology to Streptomyces clavuligerus Strain Development for Clavulanic Acid Production

Cephamycin C production was blocked in wild-type cultures of the clavulanic acid-producing organism Streptomyces clavuligerus by targeted disruption of the gene (lat) encoding lysine ɛ-aminotransferase. Specific production of clavulanic acid increased in the lat mutants derived from the wild-type st...

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Autors principals: Paradkar, A. S., Mosher, R. H., Anders, C., Griffin, A., Griffin, J., Hughes, C., Greaves, P., Barton, B., Jensen, S. E.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2001
Matèries:
Genetics and Molecular Biology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC92869/
https://ncbi.nlm.nih.gov/pubmed/11319114
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AEM.67.5.2292-2297.2001
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