Cofactor Regeneration by a Soluble Pyridine Nucleotide Transhydrogenase for Biological Production of Hydromorphone

We have applied the soluble pyridine nucleotide transhydrogenase of Pseudomonas fluorescens to a cell-free system for the regeneration of the nicotinamide cofactors NAD and NADP in the biological production of the important semisynthetic opiate drug hydromorphone. The original recombinant whole-cell...

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Bibliographic Details

Published in:	Appl Environ Microbiol
Main Authors:	Boonstra, Birgitte, Rathbone, Deborah A., French, Christopher E., Walker, Edward H., Bruce, Neil C.
Format:	Artigo
Language:	Inglês
Published:	American Society for Microbiology (ASM) 2000
Subjects:	Physiology and Biotechnology
Online Access:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC92438/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11097884/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aem.66.12.5161-5166.2000
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