Mechanism of Action of the Des-F(6) Quinolone BMS-284756 Measured by Supercoiling Inhibition and Cleavable Complex Assays

BMS-284756 (T-3811ME), a novel des-F(6) quinolone, was tested in the supercoiling inhibition and cleavable complex assays against Escherichia coli DNA gyrase, a target of quinolones. The results suggest that BMS-284756 has the same mechanism of action against DNA gyrase as other quinolones and a sim...

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Autori principali: Wu, Ping, Lawrence, Laura E., Denbleyker, Kenneth L., Barrett, John F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2001
Soggetti:
Mechanisms of Action: Physiological Effects
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC90894/
https://ncbi.nlm.nih.gov/pubmed/11709365
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.12.3660-3662.2001
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