Comparison of the Activities of Zanamivir, Oseltamivir, and RWJ-270201 against Clinical Isolates of Influenza Virus and Neuraminidase Inhibitor-Resistant Variants

RWJ-270201 is a novel cyclopentane inhibitor of influenza A and B virus neuraminidases (NAs). We compared the ability of RWJ-270201 to inhibit NA activity of clinical influenza isolates and viruses with defined resistance mutations with that of zanamivir and oseltamivir carboxylate. In NA inhibition...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Gubareva, Larisa V., Webster, Robert G., Hayden, Frederick G.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Antiviral Agents
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90844/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11709315/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.12.3403-3408.2001
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