Alterations in MurM, a Cell Wall Muropeptide Branching Enzyme, Increase High-Level Penicillin and Cephalosporin Resistance in Streptococcus pneumoniae

We report that alteration in MurM, an enzyme involved in the biosynthesis of branched-stem cell wall muropeptides, is required for maximal expression of penicillin and cefotaxime resistance in the pneumococcus. Hungarian isolate 3191 (penicillin MIC, 16 μg/ml; cefotaxime MIC, 4 μg/ml) was a source o...

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Argitaratua izan da:	Antimicrob Agents Chemother
Egile Nagusiak:	Smith, Anthony M., Klugman, Keith P.
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	American Society for Microbiology (ASM) 2001
Gaiak:	Mechanisms of Resistance
Sarrera elektronikoa:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90664/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11451707/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.8.2393-2396.2001
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