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Trifluoromethionine, a Prodrug Designed against Methionine γ-Lyase-Containing Pathogens, Has Efficacy In Vitro and In Vivo against Trichomonas vaginalis

Methionine γ-lyase, the enzyme which catalyzes the single-step conversion of methionine to α-ketobutyrate, ammonia, and methanethiol, is highly active in many anaerobic pathogenic microorganisms but has no counterpart in mammals. This study tested the hypothesis that this pathogen-specific enzyme ca...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Coombs, Graham H., Mottram, Jeremy C.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90540/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11353620/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.6.1743-1745.2001
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