Association of Amino Acid Substitutions in Penicillin-Binding Protein 3 with β-Lactam Resistance in β-Lactamase-Negative Ampicillin-Resistant Haemophilus influenzae

The affinity of [(3)H]benzylpenicillin for penicillin-binding protein (PBP) 3A was reduced in 25 clinical isolates of β-lactamase-negative ampicillin (AMP)-resistant (BLNAR) Haemophilus influenzae for which the AMP MIC was ≥1.0 μg/ml. The affinities of PBP 3B and PBP 4 were also reduced in some stra...

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Bibliographische Detailangaben
Hauptverfasser: Ubukata, Kimiko, Shibasaki, Yumi, Yamamoto, Kentarou, Chiba, Naoko, Hasegawa, Keiko, Takeuchi, Yasuo, Sunakawa, Keisuke, Inoue, Matsuhisa, Konno, Masatoshi
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2001
Schlagworte:
Mechanisms of Resistance
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC90533/
https://ncbi.nlm.nih.gov/pubmed/11353613
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.6.1693-1699.2001
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