Association of Amino Acid Substitutions in Penicillin-Binding Protein 3 with β-Lactam Resistance in β-Lactamase-Negative Ampicillin-Resistant Haemophilus influenzae

The affinity of [(3)H]benzylpenicillin for penicillin-binding protein (PBP) 3A was reduced in 25 clinical isolates of β-lactamase-negative ampicillin (AMP)-resistant (BLNAR) Haemophilus influenzae for which the AMP MIC was ≥1.0 μg/ml. The affinities of PBP 3B and PBP 4 were also reduced in some stra...

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Vydáno v:	Antimicrob Agents Chemother
Hlavní autoři:	Ubukata, Kimiko, Shibasaki, Yumi, Yamamoto, Kentarou, Chiba, Naoko, Hasegawa, Keiko, Takeuchi, Yasuo, Sunakawa, Keisuke, Inoue, Matsuhisa, Konno, Masatoshi
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	American Society for Microbiology (ASM) 2001
Témata:	Mechanisms of Resistance
On-line přístup:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90533/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11353613/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.6.1693-1699.2001
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