Selection and Characterization of Varicella-Zoster Virus Variants Resistant to (R)-9-[4-Hydroxy-2-(Hydroxymethy)Butyl]Guanine

(R)-9-[4-Hydroxy-2-(hydroxymethy)butyl]guanine (H2G) is a potent and selective inhibitor of herpesvirus replication. It is a nucleoside analog, and its triphosphate derivative (H2G-TP) is a competitive inhibitor of herpesvirus DNA polymerases. In this study, the antiviral activities of H2G and acycl...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Ng, Teresa I., Shi, Yan, Huffaker, H. Janette, Kati, Warren, Liu, Yaya, Chen, Chih-Ming, Lin, Zhen, Maring, Clarence, Kohlbrenner, William E., Molla, Akhteruzzaman
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2001
Sujets:	Antiviral Agents
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90524/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11353604/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.6.1629-1636.2001
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