Amphotericin B Lipid Complex or Amphotericin B Multiple-Dose Administration to Rabbits with Elevated Plasma Cholesterol Levels: Pharmacokinetics in Plasma and Blood, Plasma Lipoprotein Levels, Distribution in Tissues, and Renal Toxicities

The purpose of the present study was to determine if a relationship exists between the plasma cholesterol concentration, the severity of amphotericin B (AmpB)-induced renal toxicity, and the pharmacokinetics of AmpB in plasma in hypercholesterolemic rabbits administered multiple doses of amphoterici...

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Pubblicato in:	Antimicrob Agents Chemother
Autori principali:	Ramaswamy, Manisha, Peteherych, Kathy D., Kennedy, Allison L., Wasan, Kishor M.
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Microbiology (ASM) 2001
Soggetti:	Pharmacology
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90442/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11257033/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.4.1184-1191.2001
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