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Antifungal Activity and Pharmacokinetics of Posaconazole (SCH 56592) in Treatment and Prevention of Experimental Invasive Pulmonary Aspergillosis: Correlation with Galactomannan Antigenemia

The antifungal efficacy, safety, and pharmacokinetics of posaconazole (SCH 56592) (POC) were investigated in treatment and prophylaxis of primary pulmonary aspergillosis due to Aspergillus fumigatus in persistently neutropenic rabbits. Antifungal therapy consisted of POC at 2, 6, and 20 mg/kg of bod...

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Udgivet i:Antimicrob Agents Chemother
Principais autores: Petraitiene, Ruta, Petraitis, Vidmantas, Groll, Andreas H., Sein, Tin, Piscitelli, Stephen, Candelario, Myrna, Field-Ridley, Aida, Avila, Nilo, Bacher, John, Walsh, Thomas J.
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology (ASM) 2001
Fag:
Experimental Therapeutics
Online adgang:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90385/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11181372/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.3.857-869.2001
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