Influence of Prior Exposure to Zidovudine on Stavudine Phosphorylation In Vivo and Ex Vivo

Intracellular phosphorylation of stavudine (d4T) and zidovudine (ZDV) was investigated in peripheral blood mononuclear cells (PBMCs) isolated from ZDV-naive and ZDV-experienced human immunodeficiency virus (HIV)-positive patients. An in vivo study measured the amount of d4T triphosphate (d4TTP), whi...

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Bibliographic Details
Main Authors: Hoggard, P. G., Sales, S. D., Phiboonbanakit, D., Lloyd, J., Maher, B. A., Khoo, S. H., Wilkins, E., Carey, P., Hart, C. A., Back, D. J.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2001
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC90329/
https://ncbi.nlm.nih.gov/pubmed/11158757
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.45.2.577-582.2001
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