Differential Selection of Multidrug Efflux Mutants by Trovafloxacin and Ciprofloxacin in an Experimental Model of Pseudomonas aeruginosa Acute Pneumonia in Rats

The ability of trovafloxacin and ciprofloxacin to select efflux mutants in vivo was studied in a model of acute Pseudomonas aeruginosa pneumonia in rats. Twelve hours after intratracheal inoculation of 10(6) CFU of P. aeruginosa strain PAO1 enmeshed in agar beads, two groups of 12 rats were treated...

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Опубліковано в::	Antimicrob Agents Chemother
Автори:	Join-Lambert, O. F., Michéa-Hamzehpour, M., Köhler, T., Chau, F., Faurisson, F., Dautrey, S., Vissuzaine, C., Carbon, C., Pechère, J.-C.
Формат:	Artigo
Мова:	Inglês
Опубліковано:	American Society for Microbiology (ASM) 2001
Предмети:	Experimental Therapeutics
Онлайн доступ:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90328/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11158756/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.2.571-576.2001
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