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Antiviral l-Nucleosides Specific for Hepatitis B Virus Infection

A unique series of simple “unnatural” nucleosides has been discovered to inhibit hepatitis B virus (HBV) replication. Through structure-activity analysis it was found that the 3′-OH group of the β-l-2′-deoxyribose of the β-l-2′-deoxynucleoside confers specific antihepadnavirus activity. The unsubsti...

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Published in:Antimicrob Agents Chemother
Main Authors: Bryant, Martin L., Bridges, Edward G., Placidi, Laurent, Faraj, Abdesslem, Loi, Anna-Giulia, Pierra, Claire, Dukhan, David, Gosselin, Gilles, Imbach, Jean-Louis, Hernandez, Brenda, Juodawlkis, Amy, Tennant, Bud, Korba, Brent, Cote, Paul, Marion, Pat, Cretton-Scott, Erika, Schinazi, Raymond F., Sommadossi, Jean-Pierre
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2001
Subjects:
Antiviral Agents
Online Access:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90266/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11120971/
https://ncbi.nlm.nih.govhttps://doi.org/10.1128/AAC.45.1.229-235.2001
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