Interactions of Bacterial Cationic Peptide Antibiotics with Outer and Cytoplasmic Membranes of Pseudomonas aeruginosa

Polymyxins B and E1 and gramicidin S are bacterium-derived cationic antimicrobial peptides. The polymyxins were more potent than gramicidin S against Pseudomonas aeruginosa, with MICs of 0.125 to 0.25 and 8 μg/ml, respectively. These peptides differed in their affinities for binding to lipopolysacch...

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Bibliographic Details
Main Authors: Zhang, Lijuan, Dhillon, Pawandeep, Yan, Hong, Farmer, Susan, Hancock, Robert E. W.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
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Mechanisms of Action: Physiological Effects
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC90199/
https://ncbi.nlm.nih.gov/pubmed/11083634
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