Comparison of a New Triazole, Posaconazole, with Itraconazole and Amphotericin B for Treatment of Histoplasmosis following Pulmonary Challenge in Immunocompromised Mice

A murine model of intratracheally induced histoplasmosis in immunocompromised B6C3F(1) mice was used to evaluate a new triazole antifungal agent, posaconazole. This compound was previously shown to be comparable to amphotericin B and superior to itraconazole for the treatment of histoplasmosis in im...

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Autors principals: Connolly, Patricia, Wheat, L. Joseph, Schnizlein-Bick, Carol, Durkin, Michelle, Kohler, Steve, Smedema, Melinda, Goldberg, Janet, Brizendine, Edward, Loebenberg, David
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2000
Matèries:
Experimental Therapeutics
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC90122/
https://ncbi.nlm.nih.gov/pubmed/10991831
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