Effects of Fluconazole and Clarithromycin on Rifabutin and 25-O-Desacetylrifabutin Pharmacokinetics

Ten human immunodeficiency virus-infected patients were given rifabutin in addition to fluconazole and clarithromycin. There was a 76% increase in the area under the concentration-time curve of rifabutin when either fluconazole or clarithromycin was given alone and a 152% increase when both drugs we...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Jordan, M. Kelli, Polis, Michael A., Kelly, Grace, Narang, Prem K., Masur, Henry, Piscitelli, Stephen C.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Pharmacology
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90031/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10898693/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.8.2170-2172.2000
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