Effects of Fluconazole and Clarithromycin on Rifabutin and 25-O-Desacetylrifabutin Pharmacokinetics

Ten human immunodeficiency virus-infected patients were given rifabutin in addition to fluconazole and clarithromycin. There was a 76% increase in the area under the concentration-time curve of rifabutin when either fluconazole or clarithromycin was given alone and a 152% increase when both drugs we...

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Bibliographic Details
Main Authors: Jordan, M. Kelli, Polis, Michael A., Kelly, Grace, Narang, Prem K., Masur, Henry, Piscitelli, Stephen C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2000
Subjects:
Pharmacology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC90031/
https://ncbi.nlm.nih.gov/pubmed/10898693
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