Mutations in 23S rRNA and Ribosomal Protein L4 Account for Resistance in Pneumococcal Strains Selected In Vitro by Macrolide Passage

The mechanisms responsible for macrolide resistance in Streptococcus pneumoniae mutants, selected from susceptible strains by serial passage in azithromycin, were investigated. These mutants were resistant to 14- and 15-membered macrolides, but resistance could not be explained by any clinically rel...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Tait-Kamradt, A., Davies, T., Cronan, M., Jacobs, M. R., Appelbaum, P. C., Sutcliffe, J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Mechanisms of Resistance
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC90022/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10898684/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.8.2118-2125.2000
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