In Vitro Selection of Mutations in the Human Immunodeficiency Virus Type 1 Reverse Transcriptase That Decrease Susceptibility to (−)-β-d-Dioxolane-Guanosine and Suppress Resistance to 3′-Azido-3′-Deoxythymidine

Human immunodeficiency virus type 1 (HIV-1) isolates resistant to (−)-β-d-dioxolane-guanosine (DXG), a potent and selective nucleoside analog HIV-1 reverse transcriptase (RT) inhibitor, were selected by serial passage of HIV-1(LAI) in increasing drug concentrations (maximum concentration, 30 μM). Tw...

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Publié dans:	Antimicrob Agents Chemother
Auteurs principaux:	Bazmi, Holly Z., Hammond, Jennifer L., Cavalcanti, Socrates C. H., Chu, Chung K., Schinazi, Raymond F., Mellors, John W.
Format:	Artigo
Langue:	Inglês
Publié:	American Society for Microbiology (ASM) 2000
Sujets:	Antiviral Agents
Accès en ligne:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89962/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10858331/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.7.1783-1788.2000
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