Studies of the Novel Ketolide ABT-773: Transport, Binding to Ribosomes, and Inhibition of Protein Synthesis in Streptococcus pneumoniae

Macrolide resistance in Streptococcus pneumoniae has been associated with two main mechanisms: target modification by Erm methyltransferases and efflux by macrolide pumps. The ketolide ABT-773, which has a 3-keto group and no l-cladinose sugar, represents a new class of drugs with in vitro activity...

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Main Authors: Capobianco, John O., Cao, ZhenSheng, Shortridge, Virginia D., Ma, ZhenKun, Flamm, Robert K., Zhong, Ping
Format: Artigo
Sprog:Inglês
Udgivet: American Society for Microbiology 2000
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Mechanisms of Action: Physiological Effects
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC89913/
https://ncbi.nlm.nih.gov/pubmed/10817709
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