Identification and Analysis of Bacterial Protein Secretion Inhibitors Utilizing a SecA-LacZ Reporter Fusion System

Protein secretion is an essential process for bacterial growth, yet there are few if any antimicrobial agents which inhibit secretion. An in vivo, high-throughput screen to detect secretion inhibitors was developed based on the translational autoregulation of one of the central protein components, S...

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Detalhes bibliográficos

Publicado no:	Antimicrob Agents Chemother
Principais autores:	Alksne, L. E., Burgio, P., Hu, W., Feld, B., Singh, M. P., Tuckman, M., Petersen, P. J., Labthavikul, P., McGlynn, M., Barbieri, L., McDonald, L., Bradford, P., Dushin, R. G., Rothstein, D., Projan, S. J.
Formato:	Artigo
Idioma:	Inglês
Publicado em:	American Society for Microbiology (ASM) 2000
Assuntos:	Mechanisms of Action: Physiological Effects
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC89891/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/10817687/ https://ncbi.nlm.nih.govhttps://doi.org/10.1128/aac.44.6.1418-1427.2000
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